SR9009 (Stenabolic)

Rev-Erb receptors and the circadian clock

REV-ERBα and REV-ERBβ are ligand-regulated nuclear receptors that bind heme as their physiological ligand and repress transcription at ROR response elements. Within the circadian architecture they sit in the loop that represses BMAL1, and through that position they influence a broad transcriptional programme covering lipogenesis, gluconeogenesis, mitochondrial function and immune gene expression. A synthetic agonist is therefore a tool for interrogating clock-metabolism coupling rather than a metabolic drug in the conventional sense.

• Circadian gene expression amplitude and phase in cultured cells and rodent tissues
• Mitochondrial content and oxidative gene programmes in skeletal muscle
• Plasma lipid and glucose parameters in diet-induced obesity models
• Macrophage and microglial inflammatory readouts
• Exercise-capacity endpoints in rodents, the source of the exercise-mimetic framing

Interpretive problems with SR9009 data

SR9009 compared with SR9011

SR9011 is a closely related analogue from the same chemical series with a broadly similar receptor profile and the same pharmacokinetic limitations. Laboratories often run the two together, since a shared phenotype across both agonists is modestly stronger evidence for on-target action than a result from either alone.

Regulatory and status notes

Keep capsules in the sealed bottle in a cool, dry, dark place, and store the research liquid refrigerated with the cap tightly closed to limit solvent evaporation and concentration drift. Both formats are light-sensitive, so avoid prolonged bench exposure and return containers to storage promptly. Use a dedicated syringe or pipette for the liquid rather than pouring, and record lot number, concentration and date in the study log. Solutions should be checked chromatographically if held over long study windows. Handle under your laboratory's chemical hygiene plan with appropriate gloves and eye protection; research use only.