BPC-157

Origin and structure

BPC-157 corresponds to residues 14–28 of body protection compound, a protein characterised in human gastric juice. The sequence contains no cysteine and no classic protease-labile motif, and stability studies report that it survives simulated gastric conditions far longer than most peptides of comparable size. That property explains why oral and intragastric routes appear alongside parenteral ones throughout the animal literature.

Tissue-repair models

Gastrointestinal and vascular work

Analytical characterisation

Identity is normally confirmed by mass spectrometry against the expected monoisotopic mass, with purity determined by reversed-phase HPLC and reported as an area-percent value. Laboratories running quantitative assays typically verify net peptide content separately, since lyophilized material carries residual counter-ion and water that are not captured by a chromatographic purity figure.

Limits of the evidence

Vials arrive as a lyophilized cake or thin film and should be transferred to −20 °C on receipt, kept dry and shielded from light. Let a vial reach room temperature before opening so condensation does not settle on the powder. In the laboratory, reconstitution is usually performed with bacteriostatic or sterile water directed slowly down the inner vial wall rather than onto the cake; swirl gently and avoid shaking or vortexing, since mechanical foaming denatures peptide. Hold reconstituted solution at 2–8 °C, protected from light, and aliquot before any freezing step so repeated freeze–thaw cycles are avoided.