ACP-105

What a selective androgen receptor modulator is

The androgen receptor is a ligand-activated transcription factor. When bound, it translocates to the nucleus, dimerises and engages androgen response elements, recruiting coactivators and corepressors whose availability differs from tissue to tissue. Steroidal androgens are also substrates for 5-alpha-reductase and aromatase, generating dihydrotestosterone and oestradiol respectively. Non-steroidal ligands such as ACP-105 sidestep those conversions entirely, and the resulting difference in receptor conformation is the mechanistic basis on which tissue-selective effects were pursued.

Where ACP-105 sits in the class

Typical laboratory readouts

• Competitive binding affinity and transactivation potency in AR-reporter cell lines
• Tissue-weight endpoints in castrated rodent models: levator ani and prostate compared side by side
• Bone mineral density and microarchitecture by micro-CT
• Target gene expression panels distinguishing muscle from prostate transcriptional programmes
• Behavioural and cognitive batteries where central androgen receptor signalling is the variable

Regulatory and analytical context

Keep capsule bottles sealed with their desiccant at room temperature, away from light, heat and humidity, and keep the research liquid tightly capped — refrigeration slows solvent loss and extends stability. For in vitro work, prepare concentrated stocks in DMSO or ethanol, aliquot to avoid repeated freeze–thaw, and record the final vehicle percentage so it can be matched in vehicle controls; many androgen receptor reporter lines are sensitive to solvent above about 0.1%. Verify identity and purity against the lot certificate before first use, and log lot number, receipt date and opening date. Handle as a laboratory chemical: gloves, no eating or drinking at the bench, and disposal through your institution's chemical waste stream.