Prime Stack (Tesamorelin · Ipamorelin · MOTS-c vials)

Tesamorelin

Tesamorelin is the full 44-residue GHRH sequence rather than the truncated 1-29 fragment used in sermorelin, modified at the N-terminus with a trans-3-hexenoyl group. That acylation blocks the DPP-4 cleavage site responsible for the rapid inactivation of native GHRH, giving a longer-lived molecule acting at the same class B G-protein-coupled receptor on pituitary somatotrophs. It has a regulatory history in the United States for a specific indication, though the material supplied here is research grade rather than pharmaceutical.

Ipamorelin

Ipamorelin is a pentapeptide containing two non-standard residues — aminoisobutyric acid and D-2-naphthylalanine — with a C-terminal amide. It acts at GHS-R1a, the ghrelin receptor, which was characterised through secretagogue research before its endogenous ligand was identified. Its published characterisation emphasised selectivity relative to earlier secretagogues such as GHRP-6.

MOTS-c

MOTS-c stands apart from the other two. Its open reading frame lies within the mitochondrial 12S rRNA gene, making it one of a small set of mitochondrial-derived peptides. Research has associated it with AMPK activation and folate-methionine cycle intermediates, with rodent work examining metabolic homeostasis endpoints and exercise-related physiology.

Why combine pituitary and mitochondrial arms

Growth hormone axis research and cellular energetics research have historically run on separate tracks with separate assay systems. A kit spanning both allows a single study panel to look at upstream endocrine signalling and downstream cellular energy handling without mixing the two into one uninterpretable preparation.

Evidence scope

Reconstitute each vial separately and label it immediately. Warm the vial to room temperature, sanitise the stopper, add bacteriostatic water slowly down the inner wall and swirl gently until dissolved. Tesamorelin is the largest and most shear-sensitive peptide in this kit at roughly 5,136 g/mol, so avoid shaking or vortexing entirely. All three should give clear colourless solutions. Keep unopened vials sealed at −20 °C, store reconstituted material at 2–8 °C protected from light, and aliquot rather than repeatedly re-entering a single vial.