Research Peptides · Cat. 052-02
PACAP 27 amide (Human, Rat, Ovine)
Supplied as 200 µg per unit. Purity ≥ 95%. Molecular weight 3147.65. Species: Human, Ovine, Rat. Technical values shown are imported catalog fields and should be confirmed against current documentation. Laboratory research use only.
Specifications
| Catalog number | 052-02 |
|---|---|
| Product type | Research Peptides |
| Peptide family | PACAP (Pituitary Adenylate Cyclase-Activating Polypeptide) |
| Species | Human, Ovine, Rat |
| Unit size | 200 µg |
| Molecular weight | 3147.65 Da |
| Purity | ≥ 95% |
| Validation | Exhibits correct molecular weight |
| Appearance | White powder |
| Contents | Each vial contains 200 µg of NET peptide. The hop cassette of the PAC1 receptor confers coupling to Ca2+ elevation required for pituitary adenylate cyclase-activating polypeptide-evoked neurosecretion. Mustafa T, Grimaldi M, Eiden LE. J Biol Chem. 2007;282(11):8079-91. Pituitary adenylate cyclase-activating polypeptide (PACAP) 38 and PACAP4-6 are neuroprotective through inhibition of NADPH oxidase: potent regulators of microglia-mediated oxidative stress. Yang S, Yang J, Yang Z, et al. J Pharmacol Exp Ther. 2006;319(2):595-603. Pituitary adenylate cyclase-activating polypeptide 27 is a functional ligand for formyl peptide receptor-like 1. Kim Y, Lee BD, Kim O, et al. J Immunol. 2006;176(5):2969-75. Coincident elevation of cAMP and calcium influx by PACAP-27 synergistically regulates vasoactive intestinal polypeptide gene transcription through a novel PKA-independent signaling pathway. Hamelink C, Lee HW, Chen Y, Grimaldi M, Eiden LE. J Neurosci. 2002;22(13):5310-20. Both inducible and constitutive activator protein-1-like transcription factors are used for transcriptional activation of the galanin gene by different first and second messenger pathways. Anouar Y, Lee HW, Eiden LE. Mol Pharmacol. 1999;56(1):162-9. |
| Solubility | Soluble in water |
| Intended use | In vitro laboratory research only — not for human or veterinary use, diagnostic or therapeutic purposes |
Sequence
His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2
Storage & handling
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
Confirm handling and preparation requirements against current product documentation and the requirements of your laboratory protocol.
Frequently asked
What is PACAP 27 amide (Human, Rat, Ovine)?
What purity is listed for 052-02?
How should PACAP 27 amide (Human, Rat, Ovine) be stored?
What is the sequence of PACAP 27 amide (Human, Rat, Ovine)?
What is the intended use of 052-02?
This page reproduces an imported research-catalog record. Verify identity, specifications, documentation and suitability before purchase. The item is offered only for laboratory research and is not represented for human or veterinary use.