Research Peptides · Cat. 035-27A
INSL3 / RLF (Human)
Supplied as 50 µg per unit. Purity ≥ 95%. Molecular weight 6292.32. Species: Human. Technical values shown are imported catalog fields and should be confirmed against current documentation. Laboratory research use only.
Specifications
| Catalog number | 035-27A |
|---|---|
| Product type | Research Peptides |
| Peptide family | Insulin-Like Peptide 3 (INSL3) |
| Species | Human |
| Unit size | 50 µg |
| Molecular weight | 6292.32 Da |
| Purity | ≥ 95% |
| Validation | Exhibits correct molecular weight |
| Appearance | White powder |
| Contents | Each vial contains 50 μg of NET peptide. |
| B-Chain | Pro-Thr-Pro-Glu-Met-Arg-Glu-Lys-Leu-Cys-Gly-His-His-Phe-Val-Arg-Ala-Leu-Val-Arg-Val-Cys-Gly-Gly-Pro-Arg-Trp-Ser-Thr-Glu-Ala |
| Solubility | Soluble in water |
| Disulfide Bridge | CysA10-CysA15, CysA11-CysB10, CysA24-CysB22 Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain. Yeom E, Shin H, Yoo W, et al. Nat Cell Biol. 2021;23(2):172-183. Evidence for existence of insulin-like factor 3 (Insl3) hormone-receptor system in the ovarian corpus luteum and extra-ovarian reproductive organs during pregnancy in goats. Pitia AM, Minagawa I, Abe Y, et al. Cell Tissue Res. Published online February 15, 2021. Protective role of testicular hormone insl3 from atrophy and weakness in skeletal muscle. Ferlin A, De Toni L, Agoulnik AI, et al. Front Endocrinol. 2018;9:562. The testicular hormones amh, inhb, insl3, and testosterone can be independently deficient in older men. Chong YH, Pankhurst MW, McLennan IS. GERONA. Published online July 28, 2016:glw143. Insulin-like factor 3 -- a new hormone related to polycystic ovary syndrome? Szydlarska D, Grzesiuk W, Trybuch A, Kondracka A, Kowalik I, Bar-Andziak E. Endokrynol Pol. 2012;63(5):356-361. Cooperative binding of insulin-like Peptide 3 to a dimeric relaxin family peptide receptor 2. Svendsen AM, Vrecl M, Ellis TM, et al. Endocrinology. 2008;149(3):1113-20. The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells. El-shewy HM, Lee MH, Obeid LM, Jaffa AA, Luttrell LM. J Biol Chem. 2007;282(36):26150-7. The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane. Kern A, Agoulnik AI, Bryant-greenwood GD. Endocrinology. 2007;148(3):1181-94. T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane. Bogatcheva NV, Ferlin A, Feng S, et al. Am J Physiol Endocrinol Metab. 2007;292(1):E138-44. Relaxin receptors in hepatic stellate cells and cirrhotic liver. Bennett RG, Dalton SR, Mahan KJ, Gentry-nielsen MJ, Hamel FG, Tuma DJ. Biochem Pharmacol. 2007;73(7):1033-40. Relaxin receptor expression in hepatic stellate cells and in cirrhotic rat liver tissue. Bennett RG, Mahan KJ, Gentry-nielsen MJ, Tuma DJ. Ann N Y Acad Sci. 2005;1041:185-9. Relaxin-3/insulin-like peptide 5 chimeric peptide, a selective ligand for G protein-coupled receptor (GPCR)135 and GPCR142 over leucine-rich repeat-containing G protein-coupled receptor 7. Liu C, Chen J, Kuei C, et al. Mol Pharmacol. 2005;67(1):231-40. Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism. Feng S, Cortessis VK, Hwang A, et al. Urology. 2004;64(5):1032-6. Identification of relaxin-3/INSL7 as an endogenous ligand for the orphan G-protein-coupled receptor GPCR135. Liu C, Eriste E, Sutton S, et al. J Biol Chem. 2003;278(50):50754-64. Identification of relaxin-3/INSL7 as a ligand for GPCR142. Liu C, Chen J, Sutton S, et al. J Biol Chem. 2003;278(50):50765-70. GREAT/LGR8 is the only receptor for insulin-like 3 peptide. Bogatcheva NV, Truong A, Feng S, Engel W, Adham IM, Agoulnik AI. Mol Endocrinol. 2003;17(12):2639-46. |
| Research topics | Cancer Research |
| Intended use | In vitro laboratory research only — not for human or veterinary use, diagnostic or therapeutic purposes |
Sequence
Ala-Ala-Ala-Thr-Asn-Pro-Ala-Arg-Tyr-Cys-Cys-Leu-Ser-Gly-Cys-Thr-Gln-Gln-Asp-Leu-Leu-Thr-Leu-Cys-Pro-Tyr
Storage & handling
Up to 6 months in lyophilized form at 0-5ºC. For best results, rehydrate just before use. Aliquot before freezing to avoid repeated freeze-thaw cycles.
Confirm handling and preparation requirements against current product documentation and the requirements of your laboratory protocol.
Frequently asked
What is INSL3 / RLF (Human)?
INSL3 / RLF (Human) is a research peptide listed under catalog number 035-27A in the Insulin-Like Peptide 3 (INSL3) family, human sequence. It is supplied as 50 µg per unit for in vitro laboratory research.
What purity is listed for 035-27A?
The imported catalog record lists ≥ 95% (exhibits correct molecular weight). Request and verify current lot-specific documentation before purchase.
How should INSL3 / RLF (Human) be stored?
Up to 6 months in lyophilized form at 0-5ºC. For best results, rehydrate just before use. Aliquot before freezing to avoid repeated freeze-thaw cycles.
What is the sequence of INSL3 / RLF (Human)?
The 26-residue sequence is Ala-Ala-Ala-Thr-Asn-Pro-Ala-Arg-Tyr-Cys-Cys-Leu-Ser-Gly-Cys-Thr-Gln-Gln-Asp-Leu-Leu-Thr-Leu-Cys-Pro-Tyr, molecular weight 6292.32.
What is the intended use of 035-27A?
This catalog listing is for laboratory research use only. It is not represented as a drug, food, supplement, cosmetic or diagnostic product, and it is not offered for human or veterinary use.
This page reproduces an imported research-catalog record. Verify identity, specifications, documentation and suitability before purchase. The item is offered only for laboratory research and is not represented for human or veterinary use.