NAD+ Nasal Spray supplies nicotinamide adenine dinucleotide as a ready-to-use aqueous research solution in a 15 mL bottle fitted with a metered pump. NAD+ is a pyridine dinucleotide coenzyme (CAS 53-84-9) that shuttles electrons in glycolysis, the tricarboxylic acid cycle and oxidative phosphorylation, and that also serves as the consumed substrate of the sirtuin deacetylases, PARP DNA-repair enzymes and CD38 ectoenzymes. Because those consuming enzymes turn NAD+ over continuously, intracellular pools are dynamic, and NAD+ availability has become one of the more heavily studied variables in mitochondrial and cellular-aging research.
This format exists so that laboratories comparing delivery routes do not have to weigh, reconstitute and sterile-filter powder before every session. The spray arrives pre-formulated at a known concentration — 300 mg or 600 mg of NAD+ per 15 mL, i.e. 20 mg/mL or 40 mg/mL — which makes it convenient for intranasal and mucosal-absorption models where investigators want a reproducible volume per actuation rather than a volumetric dilution series.
Intranasal administration is studied because the nasal epithelium is thin, richly vascularised and adjacent to olfactory and trigeminal pathways that have been examined as routes bypassing first-pass hepatic metabolism. Whether any given molecule actually crosses in meaningful quantity is compound-specific and still under investigation, and NAD+ is a large, highly polar, negatively charged dinucleotide — which is precisely why route-comparison work on it continues. Supplied for laboratory research use only.
