Peptide Medix product catalog

Support Contact
Peptide Medix
About Peptide Medix

Shipping options shown at checkout

Confirm cost and timing before payment

Peptide Medix

GDF-8 / Myostatin Propeptide

Recombinant myostatin propeptide — the natural latency domain of GDF-8

Review catalog details Secure payments
Available to order
$123.00 $145.00 15% OFF
1
Categories: gdf-8 , myostatin , myostatin propeptide

Choose your delivery method

Standard Shipping is automatically selected at checkout. Customers can upgrade to a faster delivery option anytime.

Overview

Myostatin is synthesised as a precursor that is cleaved into a mature C-terminal dimer and an N-terminal prodomain, the propeptide. That propeptide does not simply fall away; it stays bound to the mature growth factor and holds it in a latent, receptor-inert complex until it is released by BMP-1/tolloid proteases. Supplying the propeptide on its own is therefore the most physiological way to inhibit myostatin signalling in a model system, which is why it is used as a comparator against engineered traps such as ACE-031 and against follistatin.

Specifications

Brand Peptide Medix
Category IGF & Muscle Peptides
Form Lyophilized recombinant protein in a sealed glass vial
Purity ≥95% by SDS-PAGE and HPLC; lot-matched COA available
Available sizes 1 mg
Protein class TGF-beta superfamily prodomain (latency-associated propeptide)
Gene MSTN, encoding growth differentiation factor 8
Also known as GDF-8 propeptide, myostatin prodomain, latency-associated peptide of myostatin
Mature ligand it binds Myostatin (GDF-8), a disulfide-linked homodimer of 109-residue subunits
Receptor axis ActRIIB / ActRIIA with type I receptors ALK4 and ALK5, signalling through Smad2/3
Latency release Cleavage of the propeptide by BMP-1/tolloid metalloproteinases frees the active dimer
Research areas Muscle-mass regulation, myostatin-pathway inhibition, cachexia and dystrophy models, bone and metabolic endpoints
Storage (lyophilized) −20 °C, sealed and protected from light and moisture
Storage (reconstituted) 2–8 °C for immediate work; aliquot and freeze for longer studies
Solubility Sterile or bacteriostatic water; carrier protein recommended for dilute stocks
SKU GDF-8-MYOSTATIN-1-MG

Highlights

  • Recombinant protein supplied as a lyophilized 1 mg vial, sealed and lot-numbered
  • Third-party tested for purity and identity; lot-matched certificate of analysis available
  • The natural N-terminal prodomain of GDF-8, the endogenous latency partner of mature myostatin
  • TGF-beta superfamily target acting through ActRIIB with ALK4/ALK5 and Smad2/3 signalling
  • Studied as a physiological comparator to ACE-031, follistatin and anti-myostatin antibodies
  • Handled as a recombinant protein: carrier protein for dilute stocks, no vortexing, single-use aliquots
  • Stocked and dispatched from a United States facility with insulated, discreet packing

What's Included

  • The vial option and size selected above
  • Final item and quantity confirmed in cart
  • Laboratory-research-use labeling

Research Overview

Why the propeptide is of interest

What published work has examined

  • Increases in muscle mass and fibre cross-sectional area in myostatin-inhibited rodent models.
  • Muscular dystrophy models, where myostatin blockade has been tested as a mass-preserving strategy.
  • Cancer- and disease-associated cachexia and disuse atrophy in animal studies.
  • Bone density and adiposity endpoints, reflecting myostatin signalling outside skeletal muscle.
  • Structural and biochemical work on latent-complex assembly and tolloid-mediated activation.

Interpretive and regulatory notes

GDF-8 / Myostatin Propeptide FAQ

What is the difference between GDF-8 and the myostatin propeptide?
GDF-8 is myostatin itself, the mature signalling dimer. The propeptide is the N-terminal prodomain cleaved from the same precursor, which remains bound to the mature dimer and keeps it latent. Researchers use the propeptide as an endogenous inhibitor of the ligand rather than as the ligand.
How does it compare with ACE-031 and Follistatin-344?
All three intercept signalling in the same axis but at different points. ACE-031 is an engineered soluble ActRIIB receptor that binds a broad ligand set, follistatin is a natural binding protein active against activins and myostatin, and the propeptide is myostatin's own latency domain. Selectivity differs, which is why parallel arms are common.
Is this material third-party tested?
Yes. Each lot is analysed by an independent laboratory, with purity assessed by SDS-PAGE and HPLC and identity confirmed by appropriate protein methods. The certificate of analysis is matched to the lot number printed on your vial and is available on request before or after ordering.
How should the vial be reconstituted and stored?
Sterile or bacteriostatic water added slowly down the vial wall, with gentle swirling and no vortexing. Hold the solution at 2–8 °C for immediate work, or aliquot and freeze for longer studies. Sealed lyophilized vials belong at −20 °C, protected from light and moisture.

This catalog listing is for laboratory research use only. It is not represented as a drug, food, supplement, cosmetic or diagnostic product, and it is not offered for human or veterinary use.

Customer Reviews

—
0 reviews
5 star
0%
4 star
0%
3 star
0%
2 star
0%
1 star
0%

Leave Your Review

Rating

No reviews yet — be the first!

Leave Your Review

Rating

Keep exploring

Related Products & Shopping Guides

Compare GDF-8 / Myostatin Propeptide with relevant categories, product topics, and practical shopping information.

Shop related collections

Related product topics

  • Peptide Medix IGF & Muscle
  • IGF & Muscle product options
  • gdf-8
  • myostatin
  • myostatin propeptide
  • muscle growth research
  • tgf-beta superfamily
  • recombinant protein
  • actriib signalling

Shopping information

Often researched together

Related research peptides, blends and lab supplies frequently ordered with GDF-8 / Myostatin Propeptide.

15% OFF
Follistatin-344

Peptide Medix

Follistatin-344

follistatin-344
$182.00 $215.00

View options and product details

15% OFF
ACE-031

Peptide Medix

ACE-031

ace-031
$191.00 $225.00

View options and product details

15% OFF
IGF-1 LR3

Peptide Medix

IGF-1 LR3

igf-1 lr3

2 options

$34.00 $40.00

View options and product details

15% OFF
IGF-1 DES (1-3)

Peptide Medix

IGF-1 DES (1-3)

igf-1 des

2 options

$34.00 $40.00

View options and product details

15% OFF
PEG-MGF

Peptide Medix

PEG-MGF

peg-mgf

2 options

$55.00 $65.00

View options and product details