Research Peptides · Cat. 021-03
Dynorphin A (Human, Rat, Mouse, Porcine)
Supplied as 500 µg per unit. Purity ≥ 95%. Molecular weight 2147.51. Technical values shown are imported catalog fields and should be confirmed against current documentation. Laboratory research use only.
Specifications
| Catalog number | 021-03 |
|---|---|
| Product type | Research Peptides |
| Peptide family | Dynorphin |
| Unit size | 500 µg |
| Molecular weight | 2147.51 Da |
| Purity | ≥ 95% |
| Validation | Exhibits correct molecular weight |
| Appearance | White powder |
| Contents | Each vial contains 500 µg of NET peptide. Dynorphin peptides differentially regulate the human kappa opioid receptor. Chen Y, Chen C, Liu-chen LY. Life Sci. 2007;80(15):1439-48. Ligands regulate cell surface level of the human kappa opioid receptor by activation-induced down-regulation and pharmacological chaperone-mediated enhancement: differential effects of nonpeptide and peptide agonists. Chen Y, Chen C, Wang Y, Liu-chen LY. J Pharmacol Exp Ther. 2006;319(2):765-75. Differential effects of agonists on adenylyl cyclase superactivation mediated by the kappa opioid receptors: adenylyl cyclase superactivation is independent of agonist-induced phosphorylation, desensitization, internalization, and down-regulation. Wang Y, Li JG, Huang P, Xu W, Liu-chen LY. J Pharmacol Exp Ther. 2003;307(3):1127-34. Ezrin-radixin-moesin-binding phosphoprotein-50/Na+/H+ exchanger regulatory factor (EBP50/NHERF) blocks U50,488H-induced down-regulation of the human kappa opioid receptor by enhancing its recycling rate. Li JG, Chen C, Liu-chen LY. J Biol Chem. 2002;277(30):27545-52. Femtomolar concentrations of dynorphins protect rat mesencephalic dopaminergic neurons against inflammatory damage. Liu B, Qin L, Yang SN, Wilson BC, Liu Y, Hong JS. J Pharmacol Exp Ther. 2001;298(3):1133-41. p53 Latency. C-terminal domain prevents binding of p53 core to target but not to nonspecific DNA sequences. Yakovleva T, Pramanik A, Kawasaki T, et al. J Biol Chem. 2001;276(19):15650-8. |
| Solubility | Soluble in water |
| Intended use | In vitro laboratory research only — not for human or veterinary use, diagnostic or therapeutic purposes |
Sequence
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln
Storage & handling
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
Confirm handling and preparation requirements against current product documentation and the requirements of your laboratory protocol.
Frequently asked
What is Dynorphin A (Human, Rat, Mouse, Porcine)?
What purity is listed for 021-03?
How should Dynorphin A (Human, Rat, Mouse, Porcine) be stored?
What is the sequence of Dynorphin A (Human, Rat, Mouse, Porcine)?
What is the intended use of 021-03?
This page reproduces an imported research-catalog record. Verify identity, specifications, documentation and suitability before purchase. The item is offered only for laboratory research and is not represented for human or veterinary use.