CJC-1295 DAC + Ipamorelin

CJC-1295 with DAC

The peptide is a 29-residue GHRH fragment with four amino-acid substitutions (D-Ala2, Gln8, Ala15, Leu27) chosen to resist dipeptidyl peptidase-4 cleavage and chemical degradation, plus a lysine-linked maleimidopropionyl group at the C-terminus. That maleimide reacts with the free thiol of albumin cysteine-34 shortly after entering circulation, tethering the analogue to a long-lived carrier protein. Published pharmacokinetic work reports a residence time measured in days rather than minutes, which is the defining difference from unmodified GRF analogues.

Ipamorelin

Why the combination is studied

• The two peptides engage separate receptors with separate second-messenger routes, allowing additive-versus-synergistic questions to be tested.
• Ipamorelin also acts on somatostatin tone, a mechanism distinct from direct GHRH-receptor stimulation.
• Pairing a long-acting analogue with a short-acting one lets investigators separate sustained baseline signalling from discrete pulses.

Evidence limits and design notes

Keep sealed vials at −20 °C, protected from light and moisture, and allow one to reach room temperature before opening so condensation does not reach the cake. Wipe the stopper with 70% isopropyl alcohol, then introduce bacteriostatic or sterile water slowly down the inner wall and swirl gently until dissolved; never shake or vortex, as foaming shears peptides and leaves material on the stopper. The reconstituted concentration applies to both peptides at the stated 1:1 ratio. Store the solution at 2–8 °C in the dark, label it with concentration, lot and date, avoid freeze–thaw cycles, and inspect for haze or particulates before every draw.