Research Peptides · Cat. 043-24
SHU 9119 / Melanocortin 3/4 Receptor (MC3/4R) Antagonist
Supplied as 200 µg per unit. Purity ≥ 95%. Molecular weight 1075.3. Species: Other species. Technical values shown are imported catalog fields and should be confirmed against current documentation. Laboratory research use only.
Specifications
| Catalog number | 043-24 |
|---|---|
| Product type | Research Peptides |
| Peptide family | Other Research Peptides |
| Species | Other species |
| Unit size | 200 µg |
| Molecular weight | 1075.3 Da |
| Purity | ≥ 95% |
| Validation | Exhibits correct molecular weight |
| Appearance | White powder |
| Contents | Each vial contains 200 µg of NET peptide. |
| Solubility | Soluble in water |
| Disulfide Bridge | Amide Bridge(s): Asp3-Lys8 A derivative of the melanocortin receptor antagonist SHU9119 (PG932) increases food intake when administered peripherally. Gregory M. Sutton et al., Peptides. 2008 January; 29(1): 104-111., doi: 10.1016/j.peptides.2007.10.014 Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances. Smith et al. J Physiol. 2007 Jan 15;578(Pt 2):425-38. Enterostatin inhibition of dietary fat intake is modulated through the melanocortin system. Lin et al. Peptides. 2007 Mar;28(3):643-9. Melanocortin modulation of inflammatory cytokine and neuroendocrine responses to endotoxin in the monkey. Vulliémoz et al. Endocrinology. 2006 Apr;147(4):1878-83. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. Gotoh et al. Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R202-7. Inhibition of morphine tolerance by spinal melanocortin receptor blockade. Starowicz et al. Pain. 2005 Oct;117(3):401-11. Effects of the cocaine- and amphetamine-regulated transcript peptide on the turnover of dopamine in tuberoinfundibular neurons and serum prolactin levels: studies using estrogen, melanin concentrating hormone, and melanocortin. Yang et al. Neuropharmacology. 2004 Dec;47(7):1070-80. Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats. Starowicz et al. Neurosci Lett. 2004 Mar 25;358(2):79-82. Food deprivation after treatment blocks the multiple-day hyperphagic response to SHU9119 administration. Williams et al. Brain Res. 2004 Jan 23;996(2):180-6. The catabolic action of insulin in the brain is mediated by melanocortins. Benoit et al. J Neurosci. 2002 Oct 15;22(20):9048-52. Pathophysiological role of leptin in obesity-related hypertension. Aizawa-Abe et al. J Clin Invest. 2000 May;105(9):1243-52. |
| Intended use | In vitro laboratory research only — not for human or veterinary use, diagnostic or therapeutic purposes |
Sequence
Ac-Nle-Asp-His-D-Nal(2)-Arg-Trp-Lys-NH2
Storage & handling
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
Confirm handling and preparation requirements against current product documentation and the requirements of your laboratory protocol.
Frequently asked
What is SHU 9119 / Melanocortin 3/4 Receptor (MC3/4R) Antagonist?
What purity is listed for 043-24?
How should SHU 9119 / Melanocortin 3/4 Receptor (MC3/4R) Antagonist be stored?
What is the sequence of SHU 9119 / Melanocortin 3/4 Receptor (MC3/4R) Antagonist?
What is the intended use of 043-24?
This page reproduces an imported research-catalog record. Verify identity, specifications, documentation and suitability before purchase. The item is offered only for laboratory research and is not represented for human or veterinary use.