Research Peptides · Cat. 021-55
Orphanin FQ / Nociceptin (Human, Rat, Mouse, Ox)
Supplied as 500 µg per unit. Purity ≥ 95%. Molecular weight 1809.06. Species: Human, Mouse, Ox, Rat. Technical values shown are imported catalog fields and should be confirmed against current documentation. Laboratory research use only.
Specifications
| Catalog number | 021-55 |
|---|---|
| Product type | Research Peptides |
| Peptide family | Orphanin FQ / Nociceptin |
| Species | Human, Mouse, Ox, Rat |
| Unit size | 500 µg |
| Molecular weight | 1809.06 Da |
| Purity | ≥ 95% |
| Validation | Exhibits correct molecular weight |
| Appearance | White powder |
| Contents | Each vial contains 500 µg of NET peptide. Neuropeptide orphanin FQ inhibits dendritic morphogenesis through activation of RhoA. Alder J, Kallman S, Palmieri A, et al. Dev Neurobiol. 2013;73(10):769-84. Roles of the bed nucleus of stria terminalis and of the amygdala in N/OFQ-mediated anxiety and HPA axis activation. Green MK, Barbieri EV, Brown BD, Chen KW, Devine DP. Neuropeptides. 2007;41(6):399-410. Identification of central nervous system sites involved in the water diuresis response elicited by central microinjection of nociceptin/ Orphanin FQ in conscious rats via c-Fos and inducible cAMP early repressor immunocytochemistry. Gottlieb HB, Fleming TM, Ji L, Cunningham JT. J Neuroendocrinol. 2007;19(7):531-42. Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH2] (Syn 1020) in rodents. Khroyan TV, Polgar WE, Orduna J, et al. Eur J Pharmacol. 2007;560(1):29-35. Functional interaction between nociceptin/orphanin FQ and alpha-melanocyte-stimulating hormone in the regulation of feeding. Bomberg EM, Grace MK, Levine AS, Olszewski PK. Peptides. 2006;27(7):1827-34. Tonic nociceptinergic inputs to neurons in the hypothalamic paraventricular nucleus contribute to sympathetic vasomotor tone and water and electrolyte homeostasis in conscious rats. Krowicki ZK, Kapusta DR. J Pharmacol Exp Ther. 2006;317(1):446-53. Transcriptional profiling of brain-derived-neurotrophic factor-induced neuronal plasticity: a novel role for nociceptin in hippocampal neurite outgrowth. Ring RH, Alder J, Fennell M, Kouranova E, Black IB, Thakker-varia S. J Neurobiol. 2006;66(4):361-77. Differential activation of ERK, p38, and JNK MAPK by nociceptin/orphanin FQ in the potentiation of prostaglandin cerebrovasoconstriction after brain injury. Armstead WM. Eur J Pharmacol. 2006;529(1-3):129-35. Baclofen inhibits guinea pig magnocellular neurones via activation of an inwardly rectifying K+ conductance. Slugg RM, Zheng SX, Fang Y, Kelly MJ, Rønnekleiv OK. J Physiol (Lond). 2003;551(Pt 1):295-308. Nociceptin/orphanin FQ inhibits capsaicin-induced guinea-pig airway contraction through an inward-rectifier potassium channel. Jia Y, Wang X, Aponte SI, et al. Br J Pharmacol. 2002;135(3):764-70. Comparison of pharmacological activities of buprenorphine and norbuprenorphine: norbuprenorphine is a potent opioid agonist. Huang P, Kehner GB, Cowan A, Liu-chen LY. J Pharmacol Exp Ther. 2001;297(2):688-95. Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4. Serhan CN, Fierro IM, Chiang N, Pouliot M. J Immunol. 2001;166(6):3650-4. Accelerated release and production of orphanin FQ in brain of chronic morphine tolerant rats. Yuan L, Han Z, Chang JK, Han JS. Brain Res. 1999;826(2):330-4. |
| Solubility | Soluble in water |
| Intended use | In vitro laboratory research only — not for human or veterinary use, diagnostic or therapeutic purposes |
Sequence
Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln
Storage & handling
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
Confirm handling and preparation requirements against current product documentation and the requirements of your laboratory protocol.
Frequently asked
What is Orphanin FQ / Nociceptin (Human, Rat, Mouse, Ox)?
Orphanin FQ / Nociceptin (Human, Rat, Mouse, Ox) is a research peptide listed under catalog number 021-55 in the Orphanin FQ / Nociceptin family, human / mouse / ox / rat sequence. It is supplied as 500 µg per unit for in vitro laboratory research.
What purity is listed for 021-55?
The imported catalog record lists ≥ 95% (exhibits correct molecular weight). Request and verify current lot-specific documentation before purchase.
How should Orphanin FQ / Nociceptin (Human, Rat, Mouse, Ox) be stored?
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
What is the sequence of Orphanin FQ / Nociceptin (Human, Rat, Mouse, Ox)?
The 17-residue sequence is Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln, molecular weight 1809.06.
What is the intended use of 021-55?
This catalog listing is for laboratory research use only. It is not represented as a drug, food, supplement, cosmetic or diagnostic product, and it is not offered for human or veterinary use.
This page reproduces an imported research-catalog record. Verify identity, specifications, documentation and suitability before purchase. The item is offered only for laboratory research and is not represented for human or veterinary use.