Research Peptides · Cat. 003-30
Orexin A (Human, Rat, Mouse, Porcine, Ovine, Bovine, Monkey)
Supplied as 100 µg per unit. Purity ≥ 95%. Molecular weight 3561.15. Technical values shown are imported catalog fields and should be confirmed against current documentation. Laboratory research use only.
Specifications
| Catalog number | 003-30 |
|---|---|
| Product type | Research Peptides |
| Peptide family | Orexin / Hypocretin |
| Unit size | 100 µg |
| Molecular weight | 3561.15 Da |
| Purity | ≥ 95% |
| Validation | Exhibits correct molecular weight |
| Appearance | White powder |
| Contents | Each vial contains 100 µg of NET peptide. |
| Solubility | Soluble in water |
| Disulfide Bridge | Disulfide bridge(s): Cys6-Cys12 & Cys7-Cys14 Presence, distribution and steroidogenic effect of the peptides orexin A and receptor 1 for orexins in the testis of the South American camelid alpaca (Vicugna pacos). Liguori G, Assisi L, Squillacioti C, Paino S, Mirabella N, Vittoria A. Gen Comp Endocrinol. 2012;179(1):137-42. Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neurosci. Deadwyler SA, Porrino L, Siegel JM, Hampson RE. 2007;27(52):14239-47. Hypocretin/orexin type 1 receptor in brain: role in cardiovascular control and the neuroendocrine response to immobilization stress. Samson WK, Bagley SL, Ferguson AV, White MM. Am J Physiol Regul Integr Comp Physiol. 2007;292(1):R382-7. Hypocretin-1 dose-dependently modulates maternal behaviour in mice. D'anna KL, Gammie SC. J Neuroendocrinol. 2006;18(8):553-66. PC1/3 and PC2 gene expression and post-translational endoproteolytic pro-opiomelanocortin processing is regulated by photoperiod in the seasonal Siberian hamster (Phodopus sungorus). Helwig M, Khorooshi RM, Tups A, et al. J Neuroendocrinol. 2006;18(6):413-25. Food intake in rhesus monkeys following central administration of orexins. Ramsey JJ, Kemnitz JW, Newton W, Hagopian K, Patterson TA, Swick AG. Regul Pept. 2005;124(1-3):209-14. Genomic organization of mouse orexin receptors: characterization of two novel tissue-specific splice variants. Chen J, Randeva HS. Mol Endocrinol. 2004;18(11):2790-804. Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system. Karteris E, Chen J, Randeva HS. J Clin Endocrinol Metab. 2004;89(4):1957-62. Antiallodynic effects of intrathecal orexins in a rat model of postoperative pain. Cheng JK, Chou RC, Hwang LL, Chiou LC. J Pharmacol Exp Ther. 2003;307(3):1065-71. Peptides that regulate food intake: regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation. Thorpe AJ, Mullett MA, Wang C, Kotz CM. Am J Physiol Regul Integr Comp Physiol. 2003;284(6):R1409-17. Orexin-A depolarizes nucleus tractus solitarius neurons through effects on nonselective cationic and K+ conductances. Yang B, Ferguson AV. J Neurophysiol. 2003;89(4):2167-75. Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin/Orexin peptides: implications for wakefulness and narcolepsy. Burlet S, Tyler CJ, Leonard CS. J Neurosci. 2002;22(7):2862-72. Hypocretin/orexin suppresses corticotroph responsiveness in vitro. Samson WK, Taylor MM. Am J Physiol Regul Integr Comp Physiol. 2001;281(4):R1140-5. A significant participation of orexin-A, a potent orexigenic peptide, in the preovulatory luteinizing hormone and prolactin surges in the rat. Kohsaka A, Watanobe H, Kakizaki Y, Suda T, Schiöth HB. Brain Res. 2001;898(1):166-70. Identification of receptors for neuromedin U and its role in feeding. Howard AD, Wang R, Pong SS, et al. Nature. 2000;406(6791):70-4. Agouti-related protein-like immunoreactivity: characterization of release from hypothalamic tissue and presence in serum. Li JY, Finniss S, Yang YK, et al. Endocrinology. 2000;141(6):1942-50. Pressor effects of orexins injected intracisternally and to rostral ventrolateral medulla of anesthetized rats. Chen CT, Hwang LL, Chang JK, Dun NJ. Am J Physiol Regul Integr Comp Physiol. 2000;278(3):R692-7. |
| Intended use | In vitro laboratory research only — not for human or veterinary use, diagnostic or therapeutic purposes |
Sequence
pGlu-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2
Storage & handling
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
Confirm handling and preparation requirements against current product documentation and the requirements of your laboratory protocol.
Frequently asked
What is Orexin A (Human, Rat, Mouse, Porcine, Ovine, Bovine, Monkey)?
Orexin A (Human, Rat, Mouse, Porcine, Ovine, Bovine, Monkey) is a research peptide listed under catalog number 003-30 in the Orexin / Hypocretin family. It is supplied as 100 µg per unit for in vitro laboratory research.
What purity is listed for 003-30?
The imported catalog record lists ≥ 95% (exhibits correct molecular weight). Request and verify current lot-specific documentation before purchase.
How should Orexin A (Human, Rat, Mouse, Porcine, Ovine, Bovine, Monkey) be stored?
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
What is the sequence of Orexin A (Human, Rat, Mouse, Porcine, Ovine, Bovine, Monkey)?
The 34-residue sequence is pGlu-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2, molecular weight 3561.15.
What is the intended use of 003-30?
This catalog listing is for laboratory research use only. It is not represented as a drug, food, supplement, cosmetic or diagnostic product, and it is not offered for human or veterinary use.
This page reproduces an imported research-catalog record. Verify identity, specifications, documentation and suitability before purchase. The item is offered only for laboratory research and is not represented for human or veterinary use.