Research Peptides · Cat. 043-23
Melanotan II (MTII) / Melanocortin 3/4 Receptor (MC3/4R) Agonist
Supplied as 200 µg per unit. Purity ≥ 95%. Molecular weight 1024.2. Species: Other species. Technical values shown are imported catalog fields and should be confirmed against current documentation. Laboratory research use only.
Specifications
| Catalog number | 043-23 |
|---|---|
| Product type | Research Peptides |
| Peptide family | Other Research Peptides |
| Species | Other species |
| Unit size | 200 µg |
| Molecular weight | 1024.2 Da |
| Purity | ≥ 95% |
| Validation | Exhibits correct molecular weight |
| Appearance | White powder |
| Contents | Each vial contains 200 µg of NET peptide. Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis. Vaughan C.H. et al. Brain Res. 2011 Sep 9;1411:17-27. α-Melanocyte-stimulating hormone mediates melanin-concentrating hormone-induced anorexigenic action in goldfish. Shimakura et al. Horm Behav. 2008 Feb;53(2):323-8. Dmbx1 is essential in agouti-related protein action. Fujimoto et al. Proc Natl Acad Sci USA. 2007 Sep 25;104(39):15514-9. Identification of differential melanocortin 4 receptor agonist profiles at natively expressed receptors in rat cortical astrocytes and recombinantly expressed receptors in human embryonic kidney cells. Selkirk et al. Neuropharmacology. 2007 Feb;52(2):459-66. Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances. Smith et al. J Physiol. 2007 Jan 15;578(Pt 2):425-38. Altered Hypothalamic Leptin, Insulin, and Melanocortin Binding Associated with Moderate-Fat Diet and Predisposition to Obesity. Irani et al. Endocrinology. 2007 Jan;148(1):310-6. MTII attenuates ghrelin- and food deprivation-induced increases in food hoarding and food intake. Keen-Rhinehart et al. Horm Behav. 2007 Dec;52(5):612-20. alpha-Melanocyte stimulating hormone and ghrelin: Central interaction in feeding control Olszewski et al. Peptides. 2007 Oct;28(10):2084-9. Apolipoprotein A-IV interacts synergistically with melanocortins to reduce food intake. Gotoh et al. Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R202-7. Differential effects of melanin concentrating hormone on the central dopaminergic neurons induced by the cocaine- and amphetamine-regulated transcript peptide. Yang et al. J Neurochem. 2005 Feb;92(3):637-46. Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats. Starowicz et al. Neurosci Lett. 2004 Mar 25;358(2):79-82. Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. Lu et al. J Neurosci. 2003 Aug 27;23(21):7863-72. Role of melanocortin-4 receptors in mediating renal sympathoactivation to leptin and insulin. Rahmouni et al. J Neurosci. 2003 Jul 9;23(14):5998-6004. Long-term orexigenic effects of AgRP-(83---132) involve mechanisms other than melanocortin receptor blockade. Hagan et al. Am J Physiol Regul Integr Comp Physiol. 2000 Jul;279(1):R47-52. |
| Solubility | Soluble in water |
| Intended use | In vitro laboratory research only — not for human or veterinary use, diagnostic or therapeutic purposes |
Sequence
Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2AmideBridge:Asp3-Lys8
Storage & handling
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
Confirm handling and preparation requirements against current product documentation and the requirements of your laboratory protocol.
Frequently asked
What is Melanotan II (MTII) / Melanocortin 3/4 Receptor (MC3/4R) Agonist?
Melanotan II (MTII) / Melanocortin 3/4 Receptor (MC3/4R) Agonist is a research peptide listed under catalog number 043-23 in the Other Research Peptides family, other species sequence. It is supplied as 200 µg per unit for in vitro laboratory research.
What purity is listed for 043-23?
The imported catalog record lists ≥ 95% (exhibits correct molecular weight). Request and verify current lot-specific documentation before purchase.
How should Melanotan II (MTII) / Melanocortin 3/4 Receptor (MC3/4R) Agonist be stored?
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
What is the sequence of Melanotan II (MTII) / Melanocortin 3/4 Receptor (MC3/4R) Agonist?
The 10-residue sequence is Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2AmideBridge:Asp3-Lys8, molecular weight 1024.2.
What is the intended use of 043-23?
This catalog listing is for laboratory research use only. It is not represented as a drug, food, supplement, cosmetic or diagnostic product, and it is not offered for human or veterinary use.
This page reproduces an imported research-catalog record. Verify identity, specifications, documentation and suitability before purchase. The item is offered only for laboratory research and is not represented for human or veterinary use.