Research Catalog · peptide family
Thyrotropin-Releasing Hormone (TRH) — Research Products
12 catalog items
All items are supplied for in vitro laboratory research use only — not for human or veterinary use, diagnosis or therapy. Prices are per unit as listed; each catalog number ships with its Certificate of Analysis.
Thyrotropin-Releasing Hormone (TRH) — frequently asked
What is TRH?
Thyrotropin-releasing hormone is a hypothalamic tripeptide amide, pyroglutamyl-histidyl-prolinamide. Despite its small size it acts through G protein-coupled receptors and is generally described as driving pituitary release of thyroid-stimulating hormone and prolactin.
Why is the free acid form supplied?
The C-terminal amide is reported as important for receptor binding and for resistance to degradation. The free acid version, which lacks it, serves as a negative or reduced-activity comparator in receptor binding and functional assays.
What are prepro-TRH fragments?
TRH is excised from a large precursor that also contains connecting peptides between the repeated TRH progenitor sequences. These fragments are supplied for antibody generation and for research examining whether they carry signalling activity themselves.