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TCAPs are short peptide sequences at the C-terminus of the teneurin transmembrane proteins. Four vertebrate teneurin paralogues give TCAP-1 through TCAP-4, and each peptide is studied both within its parent protein and as an isolated synthetic sequence.
Why are TCAPs compared with CRF peptides?
Reports describe limited sequence similarity between the TCAP region and the corticotropin-releasing factor family. That resemblance prompted studies of stress-related behaviour, although a shared receptor mechanism has not been firmly established and remains under investigation.
Why are the peptides biotinylated?
An N-terminal biotinylated residue provides a ready handle for streptavidin capture, letting researchers run pull-down, binding and detection experiments without additional chemistry. It also supports imaging when combined with labeled streptavidin conjugates.
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