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Members of this superfamily end in an amidated Arg-Phe motif, which is generally reported as necessary for activity at their receptors. Beyond that shared C-terminus the peptides vary considerably in length, precursor origin and receptor preference across species.
Why are RFRP peptides studied?
Mammalian RFRP-3 is widely examined as an inhibitory modulator of gonadotropin release acting through GPR147, making it a counterpart of avian gonadotropin-inhibitory hormone. Investigators use these peptides as tools in reproductive neuroendocrinology and receptor pharmacology experiments.
Which species variants are offered?
Human, rat and mouse RFRP sequences are catalogued alongside prepro fragments and non-mammalian RFamides from invertebrate and lower vertebrate sources. Sequences diverge substantially between species, so receptor assays and antibody cross-reactivity should be validated for the model in use.
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