All items are supplied for in vitro laboratory research use only — not for human or veterinary use, diagnosis or therapy.
Prices are per unit as listed; each catalog number ships with its Certificate of Analysis.
Presenilin-1 — frequently asked
What is presenilin-1?
Presenilin-1 is a multipass membrane protein that forms the catalytic core of the gamma-secretase complex, alongside nicastrin, APH-1 and PEN-2. It is itself cleaved into N-terminal and C-terminal fragments that remain associated within the active enzyme.
Why is presenilin-1 studied?
Gamma-secretase cleaves amyloid precursor protein to generate amyloid-beta peptides and processes Notch to release its signalling domain. Presenilin-1 mutations are a leading described cause of early-onset familial Alzheimer disease, making the protein central to neurodegeneration research.
Which regions are supplied as peptides?
Catalogs list synthetic peptides covering defined regions such as residues 43 to 80, 345 to 377 and 431 to 467 of the human sequence. These serve as immunogens, blocking peptides and epitope mapping tools alongside matched antibodies.
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Peptide Medix Support
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