Research Catalog · peptide family
Protein Inhibitor of nNOS (PIN) — Research Products
7 catalog items
All items are supplied for in vitro laboratory research use only — not for human or veterinary use, diagnosis or therapy. Prices are per unit as listed; each catalog number ships with its Certificate of Analysis.
Protein Inhibitor of nNOS (PIN) — frequently asked
What is PIN?
PIN is the protein inhibitor of neuronal nitric oxide synthase, a small highly conserved protein also known as dynein light chain LC8 and encoded by DYNLL1. Both names refer to the same molecule and appear interchangeably across the literature.
How does PIN relate to nNOS?
It was originally reported to inhibit neuronal nitric oxide synthase by disrupting enzyme dimerisation. That specific mechanism has been debated, and much subsequent work describes the protein more broadly as a dimerisation hub binding many partners.
Which species variants exist?
The sequence is essentially identical in human, rat and mouse, so the peptide covering residues 24-58 is supplied as a single product for all three. This conservation also means antibodies typically cross-react across these species.