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Platelet factor 4, also called CXCL4, is a small chemokine stored in platelet alpha granules and released when platelets are activated. Its highly basic C-terminal region binds heparin and other sulfated glycosaminoglycans with high affinity.
Why is PF4 studied?
Research covers its reported effects on angiogenesis, endothelial and monocyte behaviour and megakaryopoiesis, as well as its heparin-neutralising property. Complexes of PF4 with heparin are also a significant focus in immunology research.
What is CXCL4L1?
CXCL4L1, sometimes listed as the PF4 variant, is a closely related gene product differing by a small number of C-terminal residues. It is reported to differ from PF4 in glycosaminoglycan binding and in angiostatic potency.
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