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They are precursor proteins, described mainly in nematodes such as C. elegans, that are cleaved into several short neuropeptides. The label groups peptides by sequence characteristics rather than by a shared receptor, so individual members can behave quite differently.
Why are NLP peptides studied?
Synthetic NLP peptides are widely used to test candidate nematode G protein-coupled receptors in expression systems and to serve as reference standards in peptidomics. They also support behavioural and genetic work on locomotion, feeding, dauer formation and stress responses.
Which species do these peptides come from?
Most catalogue entries are C. elegans sequences, since that organism has the best-annotated NLP repertoire. Related sequences from other nematodes are sometimes studied comparatively, but conservation varies considerably between genera, so species should be checked before use.
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