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MOTS-c is a 16-residue peptide encoded by a short open reading frame inside the mitochondrial 12S ribosomal RNA gene. It is classed as a mitochondrial-derived peptide alongside humanin and the SHLP peptides, and is translated from mitochondrial rather than nuclear DNA.
Why is MOTS-c studied?
Reports describe effects on cellular energy signalling, including AMP-activated protein kinase activation and changes in folate and methionine cycle intermediates, plus associations with exercise and skeletal muscle physiology in rodent and cell models.
How well established is its mechanism?
No receptor has been identified, and several reported effects are based on cell culture or rodent studies awaiting broader replication. Findings should be described as provisional, and experimental designs should include appropriate controls and confirmation against primary sources.
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