All items are supplied for in vitro laboratory research use only — not for human or veterinary use, diagnosis or therapy.
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GHRF, also written GHRH, is a hypothalamic peptide reported to act on a class B G protein-coupled receptor on pituitary somatotrophs. In experimental systems it stimulates the synthesis and pulsatile release of growth hormone, and its N-terminal 29 residues retain most reported activity.
Why are so many analogues listed?
Native GHRF is rapidly cleaved by dipeptidyl peptidase activity, so substituted forms such as [D-Ala2]-GHRF (1-29) amide were designed for greater stability in assay conditions. N-terminally modified variants are frequently characterised as antagonists, making the set useful for structure-activity comparisons.
Which species sequences are available?
Human, bovine, rat, porcine and ovine GHRF sequences are catalogued, and they differ enough that species matching matters for receptor and immunoassay work. Antibody cross-reactivity between species should be verified against the specific sequence listed on each product page.
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