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GnIH is an avian RFamide neuropeptide first isolated from quail brain. It is reported to act through the receptor GPR147 to reduce gonadotropin synthesis and release from the pituitary, functioning as a counterweight to gonadotropin-releasing hormone in reproductive control.
Does GnIH exist in mammals?
Mammalian orthologues are described, but they are normally catalogued under the RFamide-related peptide name, with RFRP-3 regarded as the closest functional equivalent. Sequences differ appreciably from the avian peptides, so results are not transferred between the two groups without verification.
Which species variants are listed?
Chicken and quail GnIH sequences dominate, together with GnIH-related peptides 1 and 2 and short C-terminal fragments such as GnIH (8-12) amide. Labeled versions are available for tracer and detection work, and the stated species should be matched to the model.
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