All items are supplied for in vitro laboratory research use only — not for human or veterinary use, diagnosis or therapy.
Prices are per unit as listed; each catalog number ships with its Certificate of Analysis.
Farnesoid X Receptor (FXR) — frequently asked
What is the farnesoid X receptor?
FXR, also called NR1H4, is a nuclear receptor widely described as the main bile acid-activated transcription factor. It heterodimerises with the retinoid X receptor and binds inverted repeat response elements to regulate genes involved in bile acid, lipid and glucose handling.
Why is FXR studied?
Reported roles in feedback control of bile acid synthesis, hepatic and intestinal lipid handling, glucose metabolism and gut barrier function make it a frequent subject in metabolic and liver research. Defined receptor peptides support the antibody reagents that work requires.
Which species does the listed fragment cover?
The commonly catalogued FXR (446-476) sequence falls in a region conserved between human, rat and mouse, so products are labeled for all three. Even so, antibody performance differs by application, and cross-reactivity should be confirmed in the intended assay.
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