All items are supplied for in vitro laboratory research use only — not for human or veterinary use, diagnosis or therapy.
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CRAMP is the cathelin-related antimicrobial peptide of the mouse, released from a cathelicidin precursor. It is generally treated as the mouse counterpart of human LL-37 and is supplied as the mature C-terminal region of the precursor sequence.
How does CRAMP compare with LL-37?
Both are cathelicidin-derived cationic peptides with reported membrane-disrupting antimicrobial activity, but their sequences differ. Findings in mouse models are therefore usually verified against human LL-37 before conclusions are extended across species.
Why is CRAMP researched?
It is used to study innate immune defence at epithelial surfaces in mouse models, including reported antibacterial activity, chemotactic effects on immune cells, and contributions to wound repair and experimental infection systems.
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