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BAM peptides are proenkephalin A processing products first isolated from bovine adrenal medulla. They are numbered by length, such as BAM-12P and BAM-22P, and each carries the enkephalin sequence at its N-terminus with a distinguishing C-terminal extension.
Why are they studied?
They are useful because they engage more than one receptor system. The shared enkephalin N-terminus supports opioid receptor binding, while longer forms have been reported to activate Mas-related receptors on sensory neurons in a naloxone-insensitive manner.
How do BAM peptides relate to enkephalins?
Both come from the same precursor, proenkephalin A. Enkephalins are the shortest products, while BAM peptides retain that sequence plus a C-terminal extension, which is generally credited with their additional non-opioid receptor interactions.
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