Research Catalog · peptide family
Alpha-1-Antitrypsin — Research Products
11 catalog items
All items are supplied for in vitro laboratory research use only — not for human or veterinary use, diagnosis or therapy. Prices are per unit as listed; each catalog number ships with its Certificate of Analysis.
Alpha-1-Antitrypsin — frequently asked
What is alpha-1-antitrypsin?
It is an abundant plasma serine protease inhibitor encoded by SERPINA1 and the prototype member of the serpin superfamily. It is best known for inhibiting neutrophil elastase by presenting a reactive centre loop that traps the target protease.
Why are alpha-1-antitrypsin fragments studied?
Cleavage of the reactive centre loop releases short C-terminal peptides, and several of these have been reported to show immunomodulatory or antimicrobial behaviour distinct from the parent protein. Such fragments are studied as separate entities.
What are the numbered peptides used for?
Peptides covering defined residue ranges serve as immunogens, blocking peptides and epitope-mapping reagents, and as direct test substances in activity assays. Human sequences predominate, with some rat precursor fragments also listed.