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It is OXER1, a class A G protein-coupled receptor identified as the high-affinity receptor for the eicosanoid 5-oxo-ETE. Published work places it on eosinophils, neutrophils and monocytes, where it couples through Gi/o proteins to calcium mobilisation.
Why are peptides listed for a lipid receptor?
The natural ligand is a lipid, so the peptides here are short acetylated, amidated synthetic sequences supplied as reference compounds and tracers. Their selectivity for OXER1 relative to other chemoattractant receptors should be confirmed experimentally in each system.
What are the radioiodinated versions for?
I-125 labeled peptides are used in saturation and competition binding experiments on membranes or intact cells, where they provide a quantifiable tracer. The unlabeled peptide of the same sequence is typically run alongside as a competitor.
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