Research Peptides · Cat. 023-38
Endothelin B Receptor Antagonist / BQ-788
Supplied as 200 µg per unit. Purity ≥ 95%. Molecular weight 663.7. Species: Other species. Technical values shown are imported catalog fields and should be confirmed against current documentation. Laboratory research use only.
Specifications
| Catalog number | 023-38 |
|---|---|
| Product type | Research Peptides |
| Peptide family | Endothelin (ET) |
| Species | Other species |
| Unit size | 200 µg |
| Molecular weight | 663.7 Da |
| Purity | ≥ 95% |
| Validation | Exhibits correct molecular weight |
| Appearance | White powder |
| Contents | Each vial contains 200 µg of NET peptide. Endothelin-1 regulates adiponectin gene expression and secretion in 3T3-L1 adipocytes via distinct signaling pathways. Juan CC, Chuang TY, Chang CL, Huang SW, Ho LT. Endocrinology. 2007;148(4):1835-42. Endothelin-1 decreases CD36 protein expression in vascular smooth muscle cells. Kwok CF, Juan CC, Ho LT. Am J Physiol Endocrinol Metab. 2007;292(2):E648-52. Endothelin-1 induces lipolysis in 3T3-L1 adipocytes. Juan CC, Chang CL, Lai YH, Ho LT.Am J Physiol Endocrinol Metab. 2005;288(6):E1146-52. Prior antagonism of endothelin-1A receptors alleviates circulatory shock and cerebral ischemia during rat heatstroke. Liu CC, Chen ZC, Cheng BC, Lin MT. J Pharmacol Sci. 2004;96(2):177-87. Dual role of endothelin-1 via ETA and ETB receptors in regulation of cardiac contractile function in mice. Piuhola J, Mäkinen M, Szokodi I, Ruskoaho H. Am J Physiol Heart Circ Physiol. 2003;285(1):H112-8. Inotropic effects of endothelin-1: interaction with molsidomine and with BQ 610. Beyer ME, Slesak G, Hövelborn T, Kazmaier S, Nerz S, Hoffmeister HM. Hypertension. 1999;33(1):145-52. Enhanced endothelin-B-receptor-mediated vasoconstriction of small porcine coronary arteries in diet-induced hypercholesterolemia. Hasdai D, Mathew V, Schwartz RS, et al. Arterioscler Thromb Vasc Biol. 1997;17(11):2737-43. |
| Solubility | Insoluble in water. Dissolve with 0.01% ammonium hydroxide in water (pH 8.0). |
| Intended use | In vitro laboratory research only — not for human or veterinary use, diagnostic or therapeutic purposes |
Sequence
(N-cis-26-Dimethylpiperidino-carbonyl-L-γ-MeLeu-D-Trp(COOMe)-D-Nle-(ONa)
Storage & handling
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
Confirm handling and preparation requirements against current product documentation and the requirements of your laboratory protocol.
Frequently asked
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This page reproduces an imported research-catalog record. Verify identity, specifications, documentation and suitability before purchase. The item is offered only for laboratory research and is not represented for human or veterinary use.