Research Peptides · Cat. 023-01
Endothelin 1 (ET-1) (Human, Rat, Mouse, Porcine, Bovine, Canine, Rabbit, Monkey)
Supplied as 100 µg per unit. Purity ≥ 95%. Molecular weight 2491.94. Species: Bovine, Canine, Human, Monkey, Mouse, Porcine, Rabbit, Rat. Technical values shown are imported catalog fields and should be confirmed against current documentation. Laboratory research use only.
Specifications
| Catalog number | 023-01 |
|---|---|
| Product type | Research Peptides |
| Peptide family | Endothelin (ET) |
| Species | Bovine, Canine, Human, Monkey, Mouse, Porcine, Rabbit, Rat |
| Unit size | 100 µg |
| Molecular weight | 2491.94 Da |
| Purity | ≥ 95% |
| Validation | Exhibits correct molecular weight |
| Appearance | White powder |
| Contents | Each vial contains 100 µg of NET peptide. |
| Solubility | Soluble in water |
| Disulfide Bridge | Disulfide bridge(s): Cys1-Cys15 & Cys3-Cys11 Analytical validation of commercial immunoassays for the measurement of cardiovascular peptides in the dog. Schellenberg S, Grenacher B, Kaufmann K, Reusch CE, Glaus TM. Vet J. 2008;178(1):85-90. Expression of endothelin 1 and its receptors in the hypoxic pregnant rat. Thaete LG, Jilling T, Synowiec S, Khan S, Neerhof MG. Biol Reprod. 2007;77(3):526-32. Endothelin-1 and angiotensin II contribute to BNP but not c-fos gene expression response to elevated load in isolated mice hearts. Piuhola J, Szokodi I, Ruskoaho H. Biochim Biophys Acta. 2007;1772(3):338-44. Intestinal microcirculatory dysfunction during the development of experimental necrotizing enterocolitis. Ito Y, Doelle SM, Clark JA, Halpern MD, Mccuskey RS, Dvorak B. Pediatr Res. 2007;61(2):180-4. Dietary reversal of experimental hypercholesterolemia improves endothelial dysfunction of epicardial arteries but not of small coronary vessels in pigs. Sattler KJ, Galili O, Rodriguez-porcel M, Krier JD, Lerman LO, Lerman A. Atherosclerosis. 2006;188(2):301-8. Identification and characterization of binding sites for human urotensin-II in Sprague-Dawley rat renal medulla using quantitative receptor autoradiography. Disa J, Floyd LE, Edwards RM, Douglas SA, Aiyar NV. Peptides. 2006;27(6):1532-7. Dual role of endothelin-1 via ETA and ETB receptors in regulation of cardiac contractile function in mice. Piuhola J, Mäkinen M, Szokodi I, Ruskoaho H. Am J Physiol Heart Circ Physiol. 2003;285(1):H112-8. Brain natriuretic Peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases. Tsuruda T, Boerrigter G, Huntley BK, et al. Circ Res. 2002;91(12):1127-34. Dendroaspis natriuretic peptide relaxes isolated human arteries and veins. Best PJ, Burnett JC, Wilson SH, Holmes DR, Lerman A. Cardiovasc Res. 2002;55(2):375-84. Cardiotrophin-1 stimulation of cardiac fibroblast growth: roles for glycoprotein 130/leukemia inhibitory factor receptor and the endothelin type A receptor. Tsuruda T, Jougasaki M, Boerrigter G, et al. Circ Res. 2002;90(2):128-34. Simvastatin preserves coronary endothelial function in hypercholesterolemia in the absence of lipid lowering. Wilson SH, Simari RD, Best PJ, et al. Arterioscler Thromb Vasc Biol. 2001;21(1):122-8. Identification of receptors for neuromedin U and its role in feeding. Howard AD, Wang R, Pong SS, et al. Nature. 2000;406(6791):70-4. Endothelin-dependent and -independent components of strain-activated brain natriuretic peptide gene transcription require extracellular signal regulated kinase and p38 mitogen-activated protein kinase. Liang F, Lu S, Gardner DG. Hypertension. 2000;35(1 Pt 2):188-92. Enhanced endothelin-B-receptor-mediated vasoconstriction of small porcine coronary arteries in diet-induced hypercholesterolemia. Hasdai D, Mathew V, Schwartz RS, et al. Arterioscler Thromb Vasc Biol. 1997;17(11):2737-43. |
| Intended use | In vitro laboratory research only — not for human or veterinary use, diagnostic or therapeutic purposes |
Sequence
Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp
Storage & handling
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
Confirm handling and preparation requirements against current product documentation and the requirements of your laboratory protocol.
Frequently asked
What is Endothelin 1 (ET-1) (Human, Rat, Mouse, Porcine, Bovine, Canine, Rabbit, Monkey)?
Endothelin 1 (ET-1) (Human, Rat, Mouse, Porcine, Bovine, Canine, Rabbit, Monkey) is a research peptide listed under catalog number 023-01 in the Endothelin (ET) family, bovine / canine / human / monkey / mouse / porcine / rabbit / rat sequence. It is supplied as 100 µg per unit for in vitro laboratory research.
What purity is listed for 023-01?
The imported catalog record lists ≥ 95% (exhibits correct molecular weight). Request and verify current lot-specific documentation before purchase.
How should Endothelin 1 (ET-1) (Human, Rat, Mouse, Porcine, Bovine, Canine, Rabbit, Monkey) be stored?
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
What is the sequence of Endothelin 1 (ET-1) (Human, Rat, Mouse, Porcine, Bovine, Canine, Rabbit, Monkey)?
The 21-residue sequence is Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp, molecular weight 2491.94.
What is the intended use of 023-01?
This catalog listing is for laboratory research use only. It is not represented as a drug, food, supplement, cosmetic or diagnostic product, and it is not offered for human or veterinary use.
This page reproduces an imported research-catalog record. Verify identity, specifications, documentation and suitability before purchase. The item is offered only for laboratory research and is not represented for human or veterinary use.