Research Peptides · Cat. 010-01
Adrenomedullin (Human)
Supplied as 100 µg per unit. Purity ≥ 95%. Molecular weight 6028.82. Species: Human. Technical values shown are imported catalog fields and should be confirmed against current documentation. Laboratory research use only.
Specifications
| Catalog number | 010-01 |
|---|---|
| Product type | Research Peptides |
| Peptide family | Adrenomedullin (AM) |
| Species | Human |
| Unit size | 100 µg |
| Molecular weight | 6028.82 Da |
| Purity | ≥ 95% |
| Validation | Exhibits correct molecular weight |
| Appearance | White powder |
| Contents | Each vial contains 100 µg of NET peptide. |
| Solubility | Soluble in water |
| Disulfide Bridge | Disulfide bridge(s): Cys16-Cys21 Poly(lactic-co-glycolic) acid/nanohydroxyapatite scaffold containing chitosan microspheres with adrenomedullin delivery for modulation activity of osteoblasts and vascular endothelial cells. Wang L, Li C, Chen Y, Dong S, Chen X, Zhou Y. Biomed Res Int. 2013;2013:530712. Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin α5β1 and phosphorylating FAK and paxillin. Deng B, Zhang S, Miao Y, et al. J Exp Clin Cancer Res. 2012;31:19. Structure of micelle-bound adrenomedullin: a first step toward the analysis of its interactions with receptors and small molecules. Pérez-castells J, Martín-santamaría S, Nieto L, et al. Biopolymers. 2012;97(1):45-53. Intracellular proadrenomedullin-derived peptides decorate the microtubules and contribute to cytoskeleton function. Sackett DL, Ozbun L, Zudaire E, et al. Endocrinology. 2008;149(6):2888-98. Interaction of adrenomedullin and calcitonin gene-related peptide with the periodontal pathogen Porphyromonas gingivalis. Allaker RP, Sheehan BE, Mcanerney DC, Mckay IJ. FEMS Immunol Med Microbiol. 2007;49(1):91-7. Mechanisms of adrenomedullin antimicrobial action. Allaker RP, Grosvenor PW, Mcanerney DC, et al. Peptides. 2006;27(4):661-6. Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis. Zudaire E, Martínez A, Garayoa M, et al. Am J Pathol. 2006;168(1):280-91. Neuroendocrine profiling of humans receiving cardiac allografts. Ogawa T, Veinot JP, Davies RA, et al. J Heart Lung Transplant. 2005;24(8):1046-54. Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. Linscheid P, Seboek D, Zulewski H, Keller U, Müller B. Endocrinology. 2005;146(6):2699-708. Adrenomedullin protects against myocardial apoptosis after ischemia/reperfusion through activation of Akt-GSK signaling. Yin H, Chao L, Chao J. Hypertension. 2004;43(1):109-16. Regulation of adrenomedullin secretion in cultured human skin and oral keratinocytes. Kapas S, Tenchini ML, Farthing PM. J Invest Dermatol. 2001;117(2):353-9. Autocrine role of adrenomedullin in the human adrenal cortex. Thomson LM, Kapas S, Carroll M, Hinson JP. J Endocrinol. 2001;170(1):259-65. Complement factor H is a serum-binding protein for adrenomedullin, and the resulting complex modulates the bioactivities of both partners. Pio R, Martinez A, Unsworth EJ, et al. J Biol Chem. 2001;276(15):12292-300. Effects of adrenomedullin on cyclic AMP formation and on relaxation in iris sphincter smooth muscle. Yousufzai SY, Ali N, Abdel-latif AA. Invest Ophthalmol Vis Sci. 1999;40(13):3245-53. Autocrine role for the endothelin-B receptor in the secretion of adrenomedullin. Jougasaki M, Schirger JA, Simari RD, Burnett JC. Hypertension. 1998;32(5):917-22. Neutral endopeptidase inhibition potentiates the natriuretic actions of adrenomedullin. Lisy O, Jougasaki M, Schirger JA, Chen HH, Barclay PT, Burnett JC. Am J Physiol. 1998;275(3 Pt 2):F410-4. |
| Research topics | Cardiovascular Research |
| Intended use | In vitro laboratory research only — not for human or veterinary use, diagnostic or therapeutic purposes |
Sequence
Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2
Storage & handling
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
Confirm handling and preparation requirements against current product documentation and the requirements of your laboratory protocol.
Frequently asked
What is Adrenomedullin (Human)?
Adrenomedullin (Human) is a research peptide listed under catalog number 010-01 in the Adrenomedullin (AM) family, human sequence. It is supplied as 100 µg per unit for in vitro laboratory research.
What purity is listed for 010-01?
The imported catalog record lists ≥ 95% (exhibits correct molecular weight). Request and verify current lot-specific documentation before purchase.
How should Adrenomedullin (Human) be stored?
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
What is the sequence of Adrenomedullin (Human)?
The 53-residue sequence is Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2, molecular weight 6028.82.
What is the intended use of 010-01?
This catalog listing is for laboratory research use only. It is not represented as a drug, food, supplement, cosmetic or diagnostic product, and it is not offered for human or veterinary use.
This page reproduces an imported research-catalog record. Verify identity, specifications, documentation and suitability before purchase. The item is offered only for laboratory research and is not represented for human or veterinary use.