Research Peptides · Cat. 010-04
Adrenomedullin (22-52) (Human)
Supplied as 100 µg per unit. Purity ≥ 95%. Molecular weight 3576.03. Species: Human. Technical values shown are imported catalog fields and should be confirmed against current documentation. Laboratory research use only.
Specifications
| Catalog number | 010-04 |
|---|---|
| Product type | Research Peptides |
| Peptide family | Adrenomedullin (AM) |
| Species | Human |
| Unit size | 100 µg |
| Molecular weight | 3576.03 Da |
| Purity | ≥ 95% |
| Validation | Exhibits correct molecular weight |
| Appearance | White powder |
| Contents | Each vial contains 100 µg of NET peptide. Adrenomedullin expression in epithelial ovarian cancers and promotes HO8910 cell migration associated with upregulating integrin α5β1 and phosphorylating FAK and paxillin. Deng, Boya et al., Journal of Experimental & Clinical Cancer Research, March 9, 2012 Upregulated expression of intermedin and its receptor in the myocardium and aorta in spontaneously hypertensive rats. Zeng et al. Peptides. 2009 Feb;30(2):391-9. Interaction ofadrenomedullin and calcitonin gene-related peptide with the periodontal pathogen Porphyromonas gingivalis. Allaker et al. FEMS Immunol Med Microbiol. 2007 Feb;49(1):91-7. The myocardial response to adrenomedullin involves increased cAMP generation as well as augmented Akt phosphorylation. Pan et al. Peptides. 2007 Apr;28(4):900-9. Mechanisms of adrenomedullin antimicrobial action. Allaker RP, Grosvenor PW, Mcanerney DC, et al. Peptides. 2006;27(4):661-6. Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis . Zudaire et al. Am J Pathol. 2006 Jan;168(1):280-91. Intermedin 1-53 in central nervous system elevates arterial blood pressure in rats. Ren et al. Peptides. 2006 Jan;27(1):74-9. Autocrine/paracrine role of inflammation-mediated calcitonin gene-related peptide and adrenomedullin expression in human adipose tissue. Linscheid et al. Endocrinology. 2005 Jun;146(6):2699-708. Effects of adrenomedullin on cell proliferation in rat adventitia induced by aldosterone. Jiang et al. J Hypertens. 2004 Oct;22(10):1953-61. Adrenomedullin receptor binding sites in rat brain and peripheral tissues. Juaneda et al. Eur J Pharmacol. 2003 Aug 8;474(2-3):165-74 . Saturation of adrenomedullin receptors plays an important role in reducing pulmonary clearance of adrenomedullin during the late stage of sepsis. Ornan et al. Biochim Biophys Acta. 2002 Apr 24;1586(3):299-306. |
| Solubility | Soluble in water |
| Research topics | Cardiovascular Research |
| Intended use | In vitro laboratory research only — not for human or veterinary use, diagnostic or therapeutic purposes |
Sequence
Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH2
Storage & handling
Up to 6 months in lyophilized form at 0-5°C. For best results, rehydrate just before use. After rehydration, keep solution at +4°C for up to 5 days or freeze at -20°C for up to 3 months. Aliquot before freezing to avoid repeated freeze-thaw cycles.
Confirm handling and preparation requirements against current product documentation and the requirements of your laboratory protocol.
Frequently asked
What is Adrenomedullin (22-52) (Human)?
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This page reproduces an imported research-catalog record. Verify identity, specifications, documentation and suitability before purchase. The item is offered only for laboratory research and is not represented for human or veterinary use.